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The data on rhIGF-1 support the mechanistic rationale that an IGF-1 analog like LR3 (which has extended half-life and greater receptor availability in research settings) could enhance protein synthesis, stimulate cellular proliferation pathways and promote more efficient nutrient partitioning, though direct clinical trials of IGF-1 LR3 itself in humans are lacking

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Each cell carries two grades: clinical evidence (human-RCT depth for this specific outcome) and community evidence (real-world adoption)

A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy